Molecular Libraries Small Molecule Repository

The Molecular Libraries Small Molecule Repository (MLSMR) is designed to identify, acquire, maintain, and distribute to the Molecular Libraries Probe Production Centers Network (MLPCN) a collection of >300,000 chemically diverse compounds with known or unknown biological activities for use in high-throughput screening (HTS) of biological assays submitted by the research community and implemented within the centers. It is anticipated that a subset of the screening “hits” that are generated will be further developed by the MLPCN into optimized chemical analogs that can be used by the scientific community as bioactive probes to study molecular targets and cellular pathways, and potentially as starting points for therapeutics development outside of the MLPCN. The chemical structures of the compounds in the repository, along with the associated screening data obtained from the MLSCN, will be shared with the public through PubChem. A full list of compounds contained in the MLSMR can be obtained by using the search term ‘MLSMR’ in PubChem.